Targeting and surveillance mechanisms for tail-anchored proteins

Qing Qin; Kang Shen; Xiangming Wang

doi:10.59717/j.xinn-life.2023.100013

The Innovation Life > 2023 Vol. 1 > No. 1 > 100013

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Targeting and surveillance mechanisms for tail-anchored proteins

1.
Institute of Scientific and Technical Information of China, Beijing 100038, China
2.
Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA
3.
Department of Cell Biology, School of Basic Medical Science, Capital Medical University, Beijing100069, China

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Corresponding authors: kangshen@stanford.edu (K.S.); xmwang@ibp.ac.cn (X.W.)
Received Date: 15 March 2023

Accepted Date: 07 May 2023

Published Online: 25 June 2023

The Innovation Life 1(1), https://doi.org/10.59717/j.xinn-life.2023.100013 | Cite this article

GRAPHICAL ABSTRACT

GRAPHICAL ABSTRACT

PUBLIC SUMMARY

PUBLIC SUMMARY
1. Targeting specificity of tail-anchored (TA) proteins is important for their functions.
  
  Targeting and surveillance mechanisms maintain organelle specificity of TA proteins.
  
  MSP1 clears mis-targeted TA proteins from mitochondria.
  
  ATP13A1/CATP-8 extracts mis-targeted TA proteins from endoplasmic reticulum.

ABSTRACT

ABSTRACT

Tail-anchored (TA) proteins are single-pass transmembrane proteins, which contain cytosolic domains and a C-terminal transmembrane domain (TMD) anchored to organelle membranes, leaving a short tail within the lumen of organelles. Organelle specific insertion pathways exist to establish TA proteins targeting specificity. Additionally, surveillance mechanisms contribute to targeting specificity by clearing mis-targeted TA proteins. Cytosolic quality control pathways clearmis-targeted TA proteins from cytosol. MSP1 and ATP13A1/CATP-8/Spf1 extract mis-targeted TA proteins from mitochondria and ER, respectively. Here, we review the progress on the targeting and clearance mechanisms of TA proteins with a focus on ER and mitochondria proteins.

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Qin Q., Shen K., and Wang X. (2023). Targeting and surveillance mechanisms for tail-anchored proteins. The Innovation Life 1(1), 100013. https://doi.org/10.59717/j.xinn-life.2023.100013

Qin Q., Shen K., and Wang X. (2023). Targeting and surveillance mechanisms for tail-anchored proteins. The Innovation Life 1(1), 100013. https://doi.org/10.59717/j.xinn-life.2023.100013

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Targeting and surveillance mechanisms for tail-anchored proteins

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