Immune cell membrane-coated nanoparticles for targeted myocardial ischemia/reperfusion injury therapy

He Lu; Yu Wang; Ronghui Yu

doi:10.59717/j.xinn-med.2023.100015

The Innovation Medicine > 2023 Vol. 1 > No. 1 > 100015

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Immune cell membrane-coated nanoparticles for targeted myocardial ischemia/reperfusion injury therapy

1.
Department of Cardiology, National Cardiovascular Disease Regional Center for Anhui, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China
2.
Department of Cardiology, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing 210008, China
3.
Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
4.
These authors contributed equally

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Corresponding author: darcy_pann@hotmail.com
Received Date: 08 May 2023

Accepted Date: 08 June 2023

Published Online: 19 June 2023

The Innovation Medicine 1(1), https://doi.org/10.59717/j.xinn-med.2023.100015 | Cite this article

GRAPHICAL ABSTRACT

GRAPHICAL ABSTRACT

PUBLIC SUMMARY

PUBLIC SUMMARY
1. Immune cell membrane coating can endow nanoparticles with targeting ability.
  
  Cell membrane coating opens up a new field for myocardial ischemia therapy.
  
  The therapeutic effect of nanoparticles can be enhanced by cell membrane coating.

ABSTRACT

ABSTRACT

Acute myocardial infarction (MI) remains a serious disease causing lots of death and disability worldwide. Early and effective application of thrombolytic therapy or primary percutaneous coronary intervention (PCI) for myocardial reperfusion can reduce the size of MI. However, the process of recovering blood flow to the ischemic myocardium can lead to myocardial cell death, known as myocardial reperfusion injury. Due largely to the lack of therapeutic targeting and the complexity of cytokine interactions, there is still no effective treatment to protect the heart from myocardial ischemia/reperfusion injury (MIRI). Nanomedicine has always been at the forefront of medicine. However, nanoparticles (NPs) possess several limitations, such as poor targeting, biological stability, and ease of clearance by the immune system in vivo. Therefore, a method of immune cell membrane-coated NPs is proposed to solve these problems. Recently, the targeted treatment of diseases by cell membrane-encapsulated drugs has received increasing attention. The technical progress of immune cell membrane-coated NPs can realize the benefits of high targeting, high specificity, and low side effects on lesions and has great potential for treating MIRI. Herein, cell-derived membrane-coated nanosystems, their preparation process, and the applicability of these biomimetic systems in reducing MIRI injury are discussed. Finally, the prospects and challenges for their clinical translation are also introduced.

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Lu H., Wang Y., and Yu R. (2023). Immune cell membrane-coated nanoparticles for targeted myocardial ischemia/reperfusion injury therapy. The Innovation Medicine 1(1), 100015. https://doi.org/10.59717/j.xinn-med.2023.100015

Lu H., Wang Y., and Yu R. (2023). Immune cell membrane-coated nanoparticles for targeted myocardial ischemia/reperfusion injury therapy. The Innovation Medicine 1(1), 100015. https://doi.org/10.59717/j.xinn-med.2023.100015

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