A Cell Press partner journal
 
Related commentsú║
 
Add comment (English only)
Name*:
E-mail:
Telephone:
Code:  
Comments*:
 Position: Home > issue > The 2nd Issue  
Insights into hepatitis B virus DNA Integration-55 years after virus discovery
Category: Review
Author: Yuchen Xia

cc.jpg

Insights into Hepatitis B Virus DNA Integration


Hepatitis B virus (HBV), which was discovered in 1965, is a threat to global public health. HBV infects human hepatocytes and leads to acute and chronic liver diseases, and there is no cure. In cells infected by HBV, viral DNA can be integrated into the cellular genome. HBV DNA integration is a complicated process during the HBV life cycle. Although HBV integration normally results in replication-incompetent transcripts, it can still act as a template for viral protein expression. Of note, it is a primary driver of hepatocellular carcinoma (HCC). Recently, with the development of detection methods and research models, the molecular biology and the pathogenicity of HBV DNA integration have been better revealed. Here we review the advances in the research of HBV DNA integration, including molecular mechanisms, detection methods, research models, the effects on host and viral gene expression, the role of HBV integrations in the pathogenesis of HCC, and potential treatment strategies. Finally, we discuss possible future research prospects of HBV DNA integration.





[Printing]  [Close
Host:   Academic co-partner: Stay connected:
    SHANGHAI INSTITUTE OF APPLIED PHYSICS, CAS

  inquiry@the-innovation.org
  the.innovation.journal
  the.innovation.journal
  The_InnovationJ
  The Innovation┤┤đ┬
  The Innovation┤┤đ┬

Publishing partner:   INSTITUTE OF MICROBIOLOGY, CAS
  XI'AN INSTITUTE OF OPTICS AND PRECISION MECHANICS, CAS
  Copyright © 2019-2020 the-innovation.org All Rights Reserved