A Cell Press partner journal
See the unseen. Change the unchanged.
The Innovation ¡ª published by Cell Press in partnership with members of the Youth
Innovation Promotion Association (YIPA),a part of the Chinese Academy of
Sciences¡ªis a new broad-scope, open access journal publishing basic and applied
research that has impact for the benefit of society.
On the cover: Cancer is a complicated disease by genetic mutations. Loads of scientists and doctors had been making history to cancer research and clinical management. Now we're in the era of precision medicine and it is possible to conquest cancers via multidisciplinary collaboration in the near future.
  Related comments
Add comment (English only)
Name*:  
E-mail:  
Telephone:  
Code:    
Comments*:
Position: Home > issue > The 2nd Issue (August 28, 2020)
Overcoming resistance to drugs targeting KRASG12C mutation
Category:   Review   Download:  PDF  Figure  Endnote
Author: Delong Jiao, Shengyu Yang

ee.jpg

Overcoming resistance to drugs targeting KRASG12C mutation


Activating KRAS mutations are presented in 25% of human cancer. Although oncogenic Ras was deemed ¡®undruggable¡¯ in the past, recent efforts led to the development of pharmacological inhibitors targeting the KRASG12C mutant, which have shown promise in early clinical trials. The development of allele-specific K-RasG12C inhibitors marked a new chapter in targeting oncogenic KRAS mutant in cancer. However, drug resistance against these new drugs will likely limit their efficacy in the clinic. Genome-wide approaches have been used to interrogate the mechanisms of resistance to K-RasG12C inhibitors, which would facilitate the development of therapeutics overcoming drug resistance. This article reviews the latest progress in resistance to K-RasG12C-targeted therapies and aims to provide insight in future research targeting drug resistance in cancer.


Cite this article

Jiao, D. and Yang, S. Overcoming Resistance to Drugs Targeting KRASG12C Mutation. The Innovation 1 (2), 100035 (2020). doi: 10.1016/j.xinn.2020.100035





Host
ISSN 2666-6758
Publishing partner
Journal links
 
Academic co-partner
SHANGHAI INSTITUTE OF APPLIED PHYSICS, CAS
INSTITUTE OF MICROBIOLOGY, CAS
XI'AN INSTITUTE OF OPTICS AND PRECISION MECHANICS, CAS
 
Collections

Air Pollution
Astronomy
Cancer
Chemistry & Materials
COVID-19
Environment Changes
Geoscience
Life Science & Medicine
Physics
ScienceX / Interdiscipline

 
Stay connected
  the.innovation.journal
  the.innovation.journal
  The Innovation
  TheInnovation´´ÐÂ
  TheInnovation´´ÐÂ
  The_Innovation
  office@the-innovation.org
  Official£º
Astronomy£º
Chemistry£º
Geoscience£º
Informatics£º
Life Science£º
Management£º
Materials£º
Medicine£º
Physics£º
ScienceX£º

@The_InnovationJ
@Innov_Astronomy
@InnovationChem
@Innov_Geosci
@Innov_inf
@Innov_LifeSci
@Innov_MGT
@Innov_Materials
@Innov_Medicine
@InnovationPhys
@Innov_ScienceX

  Copyright © 2019-2022 the-innovation.org All Rights Reserved