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Position: Home > issue > The 3rd Issue (November 25, 2020)
Innovative Irinotecan-Loaded Nanomicelles Will Enter Phase I Clinical Trial in 2021
Category:   Translational Patent   Download:  PDF  Figure  Endnote
Author: Chan Li, Jing Xu, Yaling Gan, Xing-Jie Liang

gr1.jpg

TEM Image and Key Preclinical Results of IH-NM


Recent progress at the National Center for Nanoscience and Technology of China has enabled an extremely facile method to encapsulate irinotecan (CPT-11) into micelle-based nanoparticles (named as IH-NM). In preclinical study, compared with free CPT-11, IH-NM exhibited 1.56-fold higher maximum tolerance dose (MTD), ¡«2.70-fold higher antitumor efficacy at 80% of MTD dosage, higher plasma exposure, and slower clearance from the plasma. The IH-NM technology received Clinical Trial Permission from the National Medical Products Administration (NMPA) of China on Mar 6, 2019. The Phase I clinical trial is under preparation.


Cite this article

Li, C., Xu, J., Gan, Y. and Liang, X.-J. Innovative Irinotecan-Loaded Nanomicelles Will Enter Phase I Clinical Trial in 2021. The Innovation 1 (3), 100057 (2020). doi: 10.1016/j.xinn.2020.100057





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