TEM Image and Key Preclinical Results of IH-NM

Recent progress at the National Center for Nanoscience and Technology of China has enabled an extremely facile method to encapsulate irinotecan (CPT-11) into micelle-based nanoparticles (named as IH-NM). In preclinical study, compared with free CPT-11, IH-NM exhibited 1.56-fold higher maximum tolerance dose (MTD), ～2.70-fold higher antitumor efficacy at 80% of MTD dosage, higher plasma exposure, and slower clearance from the plasma. The IH-NM technology received Clinical Trial Permission from the National Medical Products Administration (NMPA) of China on Mar 6, 2019. The Phase I clinical trial is under preparation.

Cite this article

Li, C., Xu, J., Gan, Y. and Liang, X.-J. Innovative Irinotecan-Loaded Nanomicelles Will Enter Phase I Clinical Trial in 2021. The Innovation 1 (3), 100057 (2020). doi: 10.1016/j.xinn.2020.100057