The 1st Issue published on February 28, 2021.   A Cell Press partner journal
On the cover: White background and black font are used to commemorate the death of COVID-19 patients in this SARS-CoV-2 pandemic. We hope that, under the guide of earth sustainable development and deep space exploration, the whole world will become better and better through the humanity efforts together.
Related commentsú║
 
Add comment (English only)
Name*:
E-mail:
Telephone:
Code:  
Comments*:
 Position: Home > issue > The 3rd Issue (November 25, 2020)
RNA m6A Modification in Cancers: Molecular Mechanisms and Potential Clinical Applications
Category: Review
Author: Chang Gu, Xin Shi, Chenyang Dai, Feng Shen, Gaetano Rocco, Jiafei Chen, Zhengyu Huang, Chunji Chen, Chuan He, Tao Huang, Chang Chen

aa.png

Graphical Abstract


N6-Methyladenosine (m6A) RNA modification brings a new dawn for RNA modification researches in recent years. This posttranscriptional RNA modification is dynamic and reversible, and is regulated by methylases (í░writersí▒), demethylases (í░erasersí▒), and proteins that preferentially recognize m6A modifications (í░readersí▒). The change of RNA m6A modification regulates RNA metabolism in eucaryon, including translation, splicing, exporting, decay, and processing. Thereby the dysregulation of m6A may lead to tumorigenesis and progression. Given the tumorigenic role of abnormal m6A expression, m6A regulators may function as potential clinical therapeutic targets for cancers. In this review, we emphasize on the underlying mechanisms of m6A modifications in tumorigenesis and further introduce the potential m6A regulators-associated therapeutic targets for tumor therapy.


Cite this article

Gu, C., Shi, X., Dai, C., Shen, F., Rocco, G., Chen, J., Huang, Z., Chen, C., He, C., Huang, T. and Chen, C. RNA m6A Modification in Cancers: Molecular Mechanisms and Potential Clinical Applications. The Innovation 1 (3), 100066 (2020). doi: 10.1016/j.xinn.2020.100066





[Printing]  [Close] 
Host:   Academic co-partner: Stay connected:
    SHANGHAI INSTITUTE OF APPLIED PHYSICS, CAS

  inquiry@the-innovation.org
  the.innovation.journal
  the.innovation.journal
  The_InnovationJ
  The Innovation┤┤đ┬
  The Innovation┤┤đ┬

Publishing partner:   INSTITUTE OF MICROBIOLOGY, CAS
  XI'AN INSTITUTE OF OPTICS AND PRECISION MECHANICS, CAS
  Copyright © 2019-2021 Youth Innovation All Rights Reserved