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Position: Home > issue > February 28, 2021 Volume 2, Issue 1
Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir
Category: Report
Author: Qi Peng, Ruchao Peng, Bin Yuan, Min Wang, Jingru Zhao, Lifeng Fu, Jianxun Qi, Yi Shi

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Graphical Abstract


The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has developed into an unprecedented global pandemic. Nucleoside analogs, such as Remdesivir and Favipiravir, can serve as the first-line broad-spectrum antiviral drugs by targeting the viral polymerases. However, the underlying mechanisms for the antiviral efficacies of these drugs are far from well understood. Here, we reveal that Favipiravir, as a pyrazine derivative, could be incorporated into the viral RNA products by mimicking both adenine and guanine nucleotides.





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