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| Earth, home of human beings, is 70% water and 30% land which has nurtured splendid civilizations and flourishing lives. The cover story of this issue reflects the evolution of Earth by merging an unknown planet in a unified scene with different landscapes throughout the history such as glacier, desert, ocean, mountain, river and magma. The contrast between the past to reality can best illustrate our respect to our motherland. It is not only the subjects of geoscience studies, but also the common goal of all multidisciplinary research and the shared duties of mankind to understand, care and protect our planet to build a better future. |
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| Position: Home > issue > May 28, 2021 Volume 2, Issue 2 |
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| Acquired Resistance to Third-generation EGFR-TKIs and Emerging Next-generation EGFR Inhibitors |
Category: Review Download:  PDF  Figure  Endnote |
| Author: Xiaojing Du, Biwei Yang, Quanlin An, Yehuda G. Assaraf, Xin Cao, Jinglin Xia |
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Graphical abstract
The discovery that mutations in the EGFR gene are detected in up to 50% of lung adenocarcinoma patients, along with the development of highly efficacious epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), has revolutionized the treatment of this frequently occurring lung malignancy. Indeed, the clinical success of these TKIs constitutes a critical milestone in targeted cancer therapy. Three generations of EGFR-TKIs are currently approved for the treatment of EGFR mutation-positive non-small cell lung cancer (NSCLC).
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