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Position: Home > issue > May 28, 2021 Volume 2, Issue 2
Acquired resistance to third-generation EGFR-TKIs and emerging next-generation EGFR inhibitors
Category: Review
Author: Xiaojing Du, Biwei Yang, Quanlin An, Yehuda G. Assaraf, Xin Cao, Jinglin Xia

2.jpg

Graphical abstract


The discovery that mutations in the EGFR gene are detected in up to 50% of lung adenocarcinoma patients, along with the development of highly efficacious epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), has revolutionized the treatment of this frequently occurring lung malignancy. Indeed, the clinical success of these TKIs constitutes a critical milestone in targeted cancer therapy. Three generations of EGFR-TKIs are currently approved for the treatment of EGFR mutation-positive non-small cell lung cancer (NSCLC).





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