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On the cover: About 100,000 years ago, Diverse Homo species coexisted with our own species Homo sapiens. The Harbin cranium, or the Dragon Man, is one of the best preserved Middle Pleistocene human fossils. The cranium has a large cranial capacity falling in the range of modern humans, but is combined with a mosaic of primitive and derived characters. Phylogenetic analyses suggest that the diversification of the Homo genus had a much more distant past than previously presumed. The Harbin cranium and some other Middle Pleistocene human fossils from China represent the third human lineage that is the sister group of H. sapiens and has closer relationships with H. sapiens than Neanderthals with H. sapiens. Multiple Homo lineages in Africa, Asia and Europe probably had a strong capability for long-distance dispersal, but remained in relatively small and isolated populations. Diverse palaeoenvironments in Asia may have produced a varied biogeographic sink for human evolution.
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Position: Home > issue > August 28, 2021 Volume 2, Issue 3
On the Ultimate Finishing Line of the Human Genome Project
Category:   Commentary   Download:  PDF  Figure  Endnote
Author: Jun Yu, Songnian Hu

c2.jpg

An illustration of how the three digital systems, PDG (Personal Digital Genomes), DHS (Digital Healthcare System), and DLS (Digital Life System), are unified

The Human Genome Project (HGP) has paved the way for the Digital Personal Genomes (DPG), whereby a person's complete genome sequence serves as the primary entry for the Digital Healthcare Systems (DHS). If the goal is to deliver PDG on demand, affordability, mainly the cost, becomes one of the primary issues. However, as a once-in-a-lifetime event, a total cost of US $100 is close to $1 per year contribution. Therefore, what remains is still largely an engineering challenge, since a multi-fold reduction of the current per-genome sequencing cost may be achievable by increasing the scale of operation and the degree of automation over 5ĘC10 years.





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