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On the cover: About 100,000 years ago, Diverse Homo species coexisted with our own species Homo sapiens. The Harbin cranium, or the Dragon Man, is one of the best preserved Middle Pleistocene human fossils. The cranium has a large cranial capacity falling in the range of modern humans, but is combined with a mosaic of primitive and derived characters. Phylogenetic analyses suggest that the diversification of the Homo genus had a much more distant past than previously presumed. The Harbin cranium and some other Middle Pleistocene human fossils from China represent the third human lineage that is the sister group of H. sapiens and has closer relationships with H. sapiens than Neanderthals with H. sapiens. Multiple Homo lineages in Africa, Asia and Europe probably had a strong capability for long-distance dispersal, but remained in relatively small and isolated populations. Diverse palaeoenvironments in Asia may have produced a varied biogeographic sink for human evolution.
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Position: Home > issue > August 28, 2021 Volume 2, Issue 3
Delta.AR: An Augmented Reality-based Visualization Platform for 3D Genome
Category:   Commentary   Download:  PDF  Figure  Endnote
Author: Bixia Tang, Xiaoxing Li, Guan Li, Dong Tian, Feifei Li, Zhihua Zhang

f1.jpg

Design and screenshot of Delta.AR

Many visualization tools have been developed for 3D genome data integration using two-dimensional (2D) devices such as PC monitors or smartphones. However, the 2D surface is only suitable for displaying linear data, and it has done little to inform our understanding of the complex interconnections between 3D genome architecture and its various associated -omics data. The breakthrough in immersive display technologies, e.g., virtual reality (VR) and augmented reality (AR), has opened a completely new model for data visualization. Immersive visualization has proved a powerful way to enhance 3D structure-related research, e.g., protein structure and drug design. However, visualization in immersive mode, coupled with the integration of 3D genome and its associated -omics data, is challenging. Only a few attempts have been made for single features, e.g., Juicebox VR, which projects a Hi-C contact matrix into a virtual mountain field, and the WashU Epigenome Browser, which provides a 3D scene for epigenome tracks. A visualization tool for immersive integration of 3D genome architecture with high-dimensional -omics data has not yet been published.





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