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On the cover: About 100,000 years ago, Diverse Homo species coexisted with our own species Homo sapiens. The Harbin cranium, or the Dragon Man, is one of the best preserved Middle Pleistocene human fossils. The cranium has a large cranial capacity falling in the range of modern humans, but is combined with a mosaic of primitive and derived characters. Phylogenetic analyses suggest that the diversification of the Homo genus had a much more distant past than previously presumed. The Harbin cranium and some other Middle Pleistocene human fossils from China represent the third human lineage that is the sister group of H. sapiens and has closer relationships with H. sapiens than Neanderthals with H. sapiens. Multiple Homo lineages in Africa, Asia and Europe probably had a strong capability for long-distance dispersal, but remained in relatively small and isolated populations. Diverse palaeoenvironments in Asia may have produced a varied biogeographic sink for human evolution.
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Position: Home > issue > November 28, 2021 Volume 2, Issue 4
Mass spectrometry imaging-based multi-modal technique: Next-generation of biochemical analysis strategy
Category:   Commentary   Download:  PDF  Figure
Author: Chao Zhao, Lei Guo, Jiyang Dong, Zongwei Cai

a2.jpg

Take a typical mouse fetus imaging for example to clarify the characteristics of MSI-based multi-modal technique

Using advanced molecular imaging techniques, we can acquire the primary disturbance of spatial and temporal information based on histological variations, which has the potential to differentiate the intra-/extraheterogeneity and to predict disease progression or metastasis status in biological systems. Most of the biological and chemical imaging techniques depend on í░inherent propertiesí▒ to visualize the target compounds and their interactions from different forms of samples, such as elemental bond information, the mass-to-charge ratio (m/z), molecular fragment, ion mobility, and functional groups.





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