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On the cover: About 100,000 years ago, Diverse Homo species coexisted with our own species Homo sapiens. The Harbin cranium, or the Dragon Man, is one of the best preserved Middle Pleistocene human fossils. The cranium has a large cranial capacity falling in the range of modern humans, but is combined with a mosaic of primitive and derived characters. Phylogenetic analyses suggest that the diversification of the Homo genus had a much more distant past than previously presumed. The Harbin cranium and some other Middle Pleistocene human fossils from China represent the third human lineage that is the sister group of H. sapiens and has closer relationships with H. sapiens than Neanderthals with H. sapiens. Multiple Homo lineages in Africa, Asia and Europe probably had a strong capability for long-distance dispersal, but remained in relatively small and isolated populations. Diverse palaeoenvironments in Asia may have produced a varied biogeographic sink for human evolution.
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Position: Home > issue > November 28, 2021 Volume 2, Issue 4
Applications and potentials of nanopore sequencing in the (epi)genome and (epi)transcriptome era
Category:   Review   Download:  PDF  Figure
Author: Shangqian Xie, Amy Wing-Sze Leung, Zhenxian Zheng, Dake Zhang, Chuanle Xiao, Ruibang Luo, Ming Luo, Shoudong Zhang

a4.jpg

Graphical abstract

The Human Genome Project opened an era of (epi)genomic research, and also provided a platform for the development of new sequencing technologies. During and after the project, several sequencing technologies continue to dominate nucleic acid sequencing markets. Currently, Illumina (short-read), PacBio (long-read), and Oxford Nanopore (long-read) are the most popular sequencing technologies. Unlike PacBio or the popular short-read sequencers before it, which, as examples of the second or so-called Next-Generation Sequencing platforms, need to synthesize when sequencing, nanopore technology directly sequences native DNA and RNA molecules.





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