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On the cover: About 100,000 years ago, Diverse Homo species coexisted with our own species Homo sapiens. The Harbin cranium, or the Dragon Man, is one of the best preserved Middle Pleistocene human fossils. The cranium has a large cranial capacity falling in the range of modern humans, but is combined with a mosaic of primitive and derived characters. Phylogenetic analyses suggest that the diversification of the Homo genus had a much more distant past than previously presumed. The Harbin cranium and some other Middle Pleistocene human fossils from China represent the third human lineage that is the sister group of H. sapiens and has closer relationships with H. sapiens than Neanderthals with H. sapiens. Multiple Homo lineages in Africa, Asia and Europe probably had a strong capability for long-distance dispersal, but remained in relatively small and isolated populations. Diverse palaeoenvironments in Asia may have produced a varied biogeographic sink for human evolution.
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Position: Home > issue > November 28, 2021 Volume 2, Issue 4
Host-specific asymmetric accumulation of mutation types reveals that the origin of SARS-CoV-2 is consistent with a natural process
Category:   Article   Download:  PDF  Figure
Author: Ke-Jia Shan, Changshuo Wei, Yu Wang, Qing Huan, Wenfeng Qian

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Graphical abstract

The capacity of RNA viruses to adapt to new hosts and rapidly escape the host immune system is largely attributable to de novo genetic diversity that emerges through mutations in RNA. Although the molecular spectrum of de novo mutationsí¬the relative rates at which various base substitutions occurí¬are widely recognized as informative toward understanding the evolution of a viral genome, little attention has been paid to the possibility of using molecular spectra to infer the host origins of a virus.





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