|On the cover: On the cover: Nourished by the gigantic data and empowered by increasing computing facilities, Artificial Intelligence (AI) is setting us free from many burdensome routines. With AI muscles, we have become faster and smarter than ever. AI is reshaping the future of industries and our lives, enabling paradigm shifts in many disciplines of science and even paving the road to the metaverse. But scientists are still facing endless choices to navigate their innovation processes as previously. Meanwhile, collaborations are urgently needed amongst researchers from multidisciplinary studies. So we do hope the shared values of truth, righteousness, and peace can be cherished deeply to make our blue planet a better place for the whole ecosystem.|
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|Position: Home > issue > November 28, 2021 Volume 2, Issue 4|
|Host-specific asymmetric accumulation of mutation types reveals that the origin of SARS-CoV-2 is consistent with a natural process|
|Category: Article Download: PDF Figure Endnote|
|Author: Ke-Jia Shan, Changshuo Wei, Yu Wang, Qing Huan, Wenfeng Qian|
The capacity of RNA viruses to adapt to new hosts and rapidly escape the host immune system is largely attributable to de novo genetic diversity that emerges through mutations in RNA. Although the molecular spectrum of de novo mutations¡ªthe relative rates at which various base substitutions occur¡ªare widely recognized as informative toward understanding the evolution of a viral genome, little attention has been paid to the possibility of using molecular spectra to infer the host origins of a virus.
Shan K., Wei C., Wang Y., et al. (2021). Host-specific asymmetric accumulation of mutation types reveals that the origin of SARS-CoV-2 is consistent with a natural process. The Innovation. 2(4),100159.