A Cell Press partner journal
See the unseen. Change the unchanged.
The Innovation í¬ published by Cell Press in partnership with members of the Youth
Innovation Promotion Association (YIPA),a part of the Chinese Academy of
Sciencesí¬is a new broad-scope, open access journal publishing basic and applied
research that has impact for the benefit of society.
On the cover: On the cover: Nourished by the gigantic data and empowered by increasing computing facilities, Artificial Intelligence (AI) is setting us free from many burdensome routines. With AI muscles, we have become faster and smarter than ever. AI is reshaping the future of industries and our lives, enabling paradigm shifts in many disciplines of science and even paving the road to the metaverse. But scientists are still facing endless choices to navigate their innovation processes as previously. Meanwhile, collaborations are urgently needed amongst researchers from multidisciplinary studies. So we do hope the shared values of truth, righteousness, and peace can be cherished deeply to make our blue planet a better place for the whole ecosystem.
  Related comments
Add comment (English only)
Name*:  
E-mail:  
Telephone:  
Code:    
Comments*:
Position: Home > issue > November 28, 2021 Volume 2, Issue 4
A dual-targeted multifunctional nanoformulation for potential prevention and therapy of Alzheimer's disease
Category:   Report   Download:  PDF  Figure  Endnote
Author: Dongju Zhao, Yuqing Tang, Xinjun Suo, Chaonan Zhang, Yan Dou, Jin Chang

2.jpg

Graphical abstract

Antioxidation and adjustable treatment strategies are critical for the effective treatment of Alzheimer's disease (AD). Here, we design a dual-targeted Prussian blue nanoformulation (PTCN) that can cross the blood-brain barrier and target amyloid beta aggregates further exert antioxidant effects. An adjustable gradient dosing strategy with PTCN is used for the first time to design the preventive and therapeutic trials based on the severity of oxidative stress at different AD stages. The results show that PTCN could effectively ameliorate AD-related pathological processes, improve the cognitive decline, and rescue hippocampal atrophy of APP/PS1 mice in both preventive and therapeutic trials.


DOI:
https://doi.org/10.1016/j.xinn.2021.100160

Citation:
Zhao D., Tang Y., Suo X., et al. (2021). A dual-targeted multifunctional nanoformulation for potential prevention and therapy of Alzheimerí»s disease. The Innovation. 2(4),100160.





Host
Publishing partner
Journal links
Academic co-partner
  SHANGHAI INSTITUTE OF APPLIED PHYSICS, CAS
  INSTITUTE OF MICROBIOLOGY, CAS
  XI'AN INSTITUTE OF OPTICS AND PRECISION MECHANICS, CAS
Stay connected

  office@the-innovation.org
  the.innovation.journal
  the.innovation.journal
  The_InnovationJ
  TheInnovation┤┤đ┬
  TheInnovation┤┤đ┬
  The Innovation
  The_Innovation

  Copyright © 2019-2021 Youth Innovation All Rights Reserved