A Cell Press partner journal
See the unseen. Change the unchanged.
The Innovation ¡ª published by Cell Press in partnership with members of the Youth
Innovation Promotion Association (YIPA),a part of the Chinese Academy of
Sciences¡ªis a new broad-scope, open access journal publishing basic and applied
research that has impact for the benefit of society.
On the cover: On the cover: Nourished by the gigantic data and empowered by increasing computing facilities, Artificial Intelligence (AI) is setting us free from many burdensome routines. With AI muscles, we have become faster and smarter than ever. AI is reshaping the future of industries and our lives, enabling paradigm shifts in many disciplines of science and even paving the road to the metaverse. But scientists are still facing endless choices to navigate their innovation processes as previously. Meanwhile, collaborations are urgently needed amongst researchers from multidisciplinary studies. So we do hope the shared values of truth, righteousness, and peace can be cherished deeply to make our blue planet a better place for the whole ecosystem.
  Related comments
Add comment (English only)
Name*:  
E-mail:  
Telephone:  
Code:    
Comments*:
Position: Home > issue > November 28, 2021 Volume 2, Issue 4
Nanotechnology-enhanced immunotherapy for metastatic cancer
Category:   Review   Download:  PDF  Figure  Endnote
Author: Peisen Zhang, Junli Meng, Yingying Li, Chen Yang, Yi Hou, Wen Tang, Kevin J. McHugh, Lihong Jing

b2.jpg

Graphical Abstract

A vast majority of cancer deaths occur as a result of metastasis. Unfortunately, effective treatments for metastases are currently lacking due to the difficulty of selectively targeting these small, delocalized tumors distributed across a variety of organs. However, nanotechnology holds tremendous promise for improving immunotherapeutic outcomes in patients with metastatic cancer. In contrast to conventional cancer immunotherapies, rationally designed nanomaterials can trigger specific tumoricidal effects, thereby improving immune cell access to major sites of metastasis such as bone, lungs, and lymph nodes, optimizing antigen presentation, and inducing a persistent immune response. This paper reviews the cutting-edge trends in nano-immunoengineering for metastatic cancers with an emphasis on different nano-immunotherapeutic strategies. Specifically, it discusses directly reversing the immunological status of the primary tumor, harnessing the potential of peripheral immune cells, preventing the formation of a pre-metastatic niche, and inhibiting the tumor recurrence through postoperative immunotherapy. Lastly, we describe the challenges facing the integration of nanoscale immunomodulators and provide a forward-looking perspective on the innovative nanotechnology-based tools that may ultimately prove effective at eradicating metastatic diseases.


DOI:
https://doi.org/10.1016/j.xinn.2021.100174

Citation:
Zhang P., Meng J., Li Y., et al. (2021). Nanotechnology-enhanced immunotherapy for metastatic cancer. The Innovation. 2(4),100174.





Host
ISSN 2666-6758
Publishing partner
Journal links
 
Academic co-partner
SHANGHAI INSTITUTE OF APPLIED PHYSICS, CAS
INSTITUTE OF MICROBIOLOGY, CAS
XI'AN INSTITUTE OF OPTICS AND PRECISION MECHANICS, CAS
 
Collections

Air Pollution
Astronomy
Cancer
Chemistry
COVID-19
Environment Changes
Geoscience
Life Sciences
Materials
Medicine
Physics
ScienceX / Interdiscipline

 
Stay connected
  the.innovation.journal
  the.innovation.journal
  The Innovation
  TheInnovation´´ÐÂ
  TheInnovation´´ÐÂ
  The_Innovation
  office@the-innovation.org
  Official£º
Astronomy£º
Chemistry£º
Geoscience£º
Informatics£º
Life Science£º
Management£º
Materials£º
Medicine£º
Physics£º
ScienceX£º

@The_InnovationJ
@Innov_Astronomy
@InnovationChem
@Innov_Geosci
@Innov_inf
@Innov_LifeSci
@Innov_MGT
@Innov_Materials
@Innov_Medicine
@InnovationPhys
@Innov_ScienceX

  Copyright © 2019-2022 the-innovation.org All Rights Reserved