|
 |
| On the cover: On the cover: Vivid life is everywhere in this blue planet. In this cover, four seasons are illustrated with diverse lives that are the traces of entire ecosystem circle. What a natural harmony! From birth to death, each species has its own life cycle and innate mechanisms decoded and to be decoded by scientists. The destiny of life cycle can be revealed by genome within a cell as the core of living beings. The more scientific discoveries about the core, the higher possibilities to disclose the truth of life. For sustainable development of our planet, it is important to build up one co-existing ecosystem for all living things. |
|
|
| Add comment (English only) |
|
|
|
|
|
| Position: Home > issue > January 25, 2022 Volume 3, Issue 1 |
|
|
|
| DCLK1 autoinhibition and activation in tumorigenesis |
Category: Report Download:  PDF  Figure  Endnote |
| Author: Linna Cheng, Zejing Yang, Wenhao Guo, Chengyong Wu, Shufang Liang, Aiping Tong, Zhongwei Cao, Rick F. Thorne, Sheng-Yong Yang, Yamei Yu, Qiang Chen |
|
|
Graphical abstract Doublecortin-like kinase 1 (DCLK1) is upregulated in many tumors and is a marker for tumor stem cells. Accumulating evidence suggests DCLK1 constitutes a promising drug target for cancer therapy. However, the regulation of DCLK1 kinase activity is poorly understood, particularly the function of its autoinhibitory domain (AID), and, moreover, no physiological activators of DCLK1 have presently been reported. Here we determined the first DCLK1 kinase structure in the autoinhibited state and identified the neuronal calcium sensor HPCAL1 as an activator of DCLK1.
|
|
|
|
TheInnovation´´ÐÂ
TheInnovation´´ÐÂ
The_Innovation
office@the-innovation.org
Official£º