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Position: Home > issue > January 25, 2022 Volume 3, Issue 1
DCLK1 autoinhibition and activation in tumorigenesis
Category:   Report   Download:  PDF  Figure  Endnote
Author: Linna Cheng, Zejing Yang, Wenhao Guo, Chengyong Wu, Shufang Liang, Aiping Tong, Zhongwei Cao, Rick F. Thorne, Sheng-Yong Yang, Yamei Yu, Qiang Chen

1111.jpg

Graphical abstract

Doublecortin-like kinase 1 (DCLK1) is upregulated in many tumors and is a marker for tumor stem cells. Accumulating evidence suggests DCLK1 constitutes a promising drug target for cancer therapy. However, the regulation of DCLK1 kinase activity is poorly understood, particularly the function of its autoinhibitory domain (AID), and, moreover, no physiological activators of DCLK1 have presently been reported. Here we determined the first DCLK1 kinase structure in the autoinhibited state and identified the neuronal calcium sensor HPCAL1 as an activator of DCLK1.





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