A Cell Press partner journal
See the unseen. Change the unchanged.
The Innovation ¡ª published by Cell Press in partnership with members of the Youth
Innovation Promotion Association (YIPA),a part of the Chinese Academy of
Sciences¡ªis a new broad-scope, open access journal publishing basic and applied
research that has impact for the benefit of society.
On the cover: On the cover: Vivid life is everywhere in this blue planet. In this cover, four seasons are illustrated with diverse lives that are the traces of entire ecosystem circle. What a natural harmony! From birth to death, each species has its own life cycle and innate mechanisms decoded and to be decoded by scientists. The destiny of life cycle can be revealed by genome within a cell as the core of living beings. The more scientific discoveries about the core, the higher possibilities to disclose the truth of life. For sustainable development of our planet, it is important to build up one co-existing ecosystem for all living things.
  Related comments
Add comment (English only)
Name*:  
E-mail:  
Telephone:  
Code:    
Comments*:
Position: Home > issue > January 25, 2022 Volume 3, Issue 1
Profiling of immune features to predict immunotherapy efficacy
Category:   Article   Download:  PDF  Figure  Endnote
Author: Youqiong Ye, Yongchang Zhang, Nong Yang, Qian Gao, Xinyu Ding, Xinwei Kuang, Rujuan Bao, Zhao Zhang, Chaoyang Sun, Bingying Zhou, Li Wang, Qingsong Hu, Chunru Lin, Jianjun Gao, Yanyan Lou, Steven H. Lin, Lixia Diao, Hong Liu, Xiang Chen

1111.jpg

Graphical abstract

Immune checkpoint blockade (ICB) therapies exhibit substantial clinical benefit in different cancers, but relatively low response rates in the majority of patients highlight the need to understand mutual relationships among immune features. Here, we reveal overall positive correlations among immune checkpoints and immune cell populations. Clinically, patients benefiting from ICB exhibited increases for both immune stimulatory and inhibitory features after initiation of therapy, suggesting that the activation of the immune microenvironment might serve as the biomarker to predict immune response.


DOI:
https://doi.org/10.1016/j.xinn.2021.100194

Citation:
Ye Y., Zhang Y., Yang N., et al. (2021). Profiling of immune features to predict immunotherapy efficacy. The Innovation. 3(1),100194.





Host
ISSN 2666-6758
Publishing partner
Journal links
 
Academic co-partner
SHANGHAI INSTITUTE OF APPLIED PHYSICS, CAS
INSTITUTE OF MICROBIOLOGY, CAS
XI'AN INSTITUTE OF OPTICS AND PRECISION MECHANICS, CAS
 
Collections

Air Pollution
Astronomy
Cancer
Chemistry & Materials
COVID-19
Environment Changes
Geoscience
Life Science & Medicine
Physics
ScienceX / Interdiscipline

 
Stay connected
  the.innovation.journal
  the.innovation.journal
  The Innovation
  TheInnovation´´ÐÂ
  TheInnovation´´ÐÂ
  The_Innovation
  office@the-innovation.org
  Official£º
Astronomy£º
Chemistry£º
Geoscience£º
Informatics£º
Life Science£º
Management£º
Materials£º
Medicine£º
Physics£º
ScienceX£º

@The_InnovationJ
@Innov_Astronomy
@InnovationChem
@Innov_Geosci
@Innov_inf
@Innov_LifeSci
@Innov_MGT
@Innov_Materials
@Innov_Medicine
@InnovationPhys
@Innov_ScienceX

  Copyright © 2019-2022 the-innovation.org All Rights Reserved