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Position: Home > issue > March 29, 2022 Volume 3, Issue 2
A highly immunogenic live-attenuated vaccine candidate prevents SARS-CoV-2 infection and transmission in hamsters
Category:   Report   Download:  PDF  Figure  Endnote
Author: Xiao-Feng Li, Zhen Cui, Hang Fan, Qi Chen, Lei Cao, Hong-Ying Qiu, Na-Na Zhang, Yan-Peng Xu, Rong-Rong Zhang, Chao Zhou, Qing Ye, Yong-Qiang Deng, Yan Guo, Si Qin, Kaiyue Fan, Lei Wang, Zijing Jia, Yujun Cui, Xiangxi Wang, Cheng-Feng Qin

The highly pathogenic and readily transmissible SARS-CoV-2 has caused a global coronavirus pandemic, urgently requiring effective countermeasures against its rapid expansion. All available vaccine platforms are being utilized to generate safe and effective COVID-19 vaccines. Here, we generated a live-attenuated candidate vaccine strain by serial passaging of a SARS-CoV-2 clinical isolate in Vero cells. Deep sequencing revealed the dynamic adaptation of SARS-CoV-2 in Vero cells, resulting in a stable clone with a deletion of seven amino acids (N679SPRRAR685) at the S1/S2 junction of the S protein (named VAS5).





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