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Position: Home > issue > May 10, 2022 Volume 3, Issue 3
Revolution of vitamin E production by starting from microbial fermented farnesene to isophytol
Category:   Report   Download:  PDF  Figure  Endnote
Author: Ziling Ye, Bin Shi, Yanglei Huang, Tian Ma, Zilei Xiang, Ben Hu, Zhaolin Kuang, Man Huang, Xiaoying Lin, Zhu Tian, Zixin Deng, Kun Shen, Tiangang Liu

a1.jpg

GRAPHICAL ABSTRACT

Vitamin E is one of the most widely used vitamins. In the classical commercial synthesis of vitamin E (¦Á-tocopherol), the chemical synthesis of isophytol is the key technical barrier. Here, we establish a new process for isophytol synthesis from microbial fermented farnesene. To achieve an efficient pathway for farnesene production, Saccharomyces cerevisiae was selected as the host strain. First, ¦Â-farnesene synthase genes from different sources were screened, and through protein engineering and system metabolic engineering, a high production of ¦Â-farnesene in S. cerevisiae was achieved (55.4 g/L).





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