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| On the cover: Medicine is the practice of the diagnosis, treatment, and prevention of disease. With the advances in medical science, human beings are getting both longer life spans and higher quality of life. From herbs to molecular signatures, humankind is experiencing a transition from traditional medicine to personalized medicine: the right treatment to the right patient at the right time. However, it is not so easy to achieve this goal because the etiology of most diseases and disorders is still unclear. From description to association, numerous researchers are working together to decipher the mechanisms behind disease. To address such challenges, more and more global collaborations are badly needed to include experts from all disciplines: not just doctors, scientists and administration staff, but also engineers, technicians and marketing managers. Not limited to a fish-eye view, we humans should widen our vision and get more deep insights beyond the human community. That is the right way to assure sustainable healthcare for humanity. |
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| Position: Home > issue > May 10, 2022 Volume 3, Issue 3 |
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| Anticancer drug R&D of gastrointestinal cancer in China: Current landscape and challenges |
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Challenges in gastrointestinal cancer and strategies in anticancer drug discovery
According to the latest report of cancer epidemiology published in 2022, about 1,500,000 new cases of gastrointestinal (GI) cancers were diagnosed in China, with 1,077,000 registered deaths.1 Both the GI cancer incidence and related deaths in China account for about 50% around the world, and the GI cancer burden is still increasing globally.2 Therefore, Chinese researchers have the responsibility to play a leading role in the prevention, diagnosis, and treatment of GI cancer. For advanced GI cancers, despite progress of conventional chemotherapy, target therapy, and even immunotherapy, long-term survival of patients is still relatively low.
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