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| On the cover: Medicine is the practice of the diagnosis, treatment, and prevention of disease. With the advances in medical science, human beings are getting both longer life spans and higher quality of life. From herbs to molecular signatures, humankind is experiencing a transition from traditional medicine to personalized medicine: the right treatment to the right patient at the right time. However, it is not so easy to achieve this goal because the etiology of most diseases and disorders is still unclear. From description to association, numerous researchers are working together to decipher the mechanisms behind disease. To address such challenges, more and more global collaborations are badly needed to include experts from all disciplines: not just doctors, scientists and administration staff, but also engineers, technicians and marketing managers. Not limited to a fish-eye view, we humans should widen our vision and get more deep insights beyond the human community. That is the right way to assure sustainable healthcare for humanity. |
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| Position: Home > issue > May 10, 2022 Volume 3, Issue 3 |
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| Toripalimab in advanced biliary tract cancer |
Category: Report Download:  PDF  Figure  Endnote |
| Author: Wei Li, Yueqi Wang, Yiyi Yu, Qian Li, Yan Wang, Chenlu Zhang, Xiaojing Xu, Xi Guo, Yu Dong, Yuehong Cui, Qing Hao, Lujia Huang, Houbao Liu, Tianshu Liu |
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GRAPHICAL ABSTRACT
Gemcitabine combined with platinum/fluorouracil drugs is the standard first-line treatment for advanced biliary tract cancers (BTCs). This study explored the safety and efficacy of Toripalimab plus gemcitabine and S-1 (GS) as the first-line treatment for advanced BTCs. At a one-sided significance level of 0.025, a total of 50 patients could provide 80% power to show the efficacy at targeted progression free survival rate at 6 months of 70% versus 40% for the combined treatment. This single-arm, phase II study enrolled 50 patients with advanced BTCs who previously received no systemic treatment.
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