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On the cover: The rising in the popularity of big data, artificial intelligence, and simulation technologies has opened up new opportunities for the development of our society. The close integration of real and artificial societies has become a trend, bringing in novel concepts such as parallel society and metaverse. The artificial society system describes, predicts, and guides the real society system, in a closed-loop, iterative, and spiral-rising way, forming a new mode of social operation driven by Data-AI-Simulation techniques. In the future, with the further development of interdisciplinary cooperation and the continuous advancement of technologies, living in metaverse is within reach. |
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Position: Home > issue > September 13, 2022 Volume 3, Issue 5 |
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Opening up the black box of human cell plasticity |
Category: Commentary Download: PDF Figure Endnote |
Author: Yusheng Cai, Juan Carlos Izpisua Belmonte, Jing Qu, Guang-Hui Liu, Weiqi Zhang |
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Historical view of the development of reprogramming and schematic of chemical reprogramming from somatic cells to human CiPSCs
Cell plasticity represents the ability of cells to acquire new characteristics. Cell plasticity can be reset in somatic cells via cellular reprogramming, a process that occurs in regeneration. However, cell plasticity occurs rarely in humans. Recently, Guan et al. recreated cell plasticity in mature human cells, which they found to be essential for reprogramming human somatic cells to pluripotent stem cells using only small molecules. As the first study demonstrates that chemical compounds can completely reprogram human somatic cells to a pluripotent state, it is a paradigm shift in developing pharmacological or therapeutic reprogramming approaches to control human cells.

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