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| On the cover: The rising in the popularity of big data, artificial intelligence, and simulation technologies has opened up new opportunities for the development of our society. The close integration of real and artificial societies has become a trend, bringing in novel concepts such as parallel society and metaverse. The artificial society system describes, predicts, and guides the real society system, in a closed-loop, iterative, and spiral-rising way, forming a new mode of social operation driven by Data-AI-Simulation techniques. In the future, with the further development of interdisciplinary cooperation and the continuous advancement of technologies, living in metaverse is within reach. |
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| Position: Home > issue > September 13, 2022 Volume 3, Issue 5 |
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| Unlocking the secrets to human NTCP structure |
Category: Commentary Download:  PDF  Figure  Endnote |
| Author: Xiangbing Qi, Wenhui Li |
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The cryoelectron microscopy structures of NTCP
Sodium taurocholate co-transporting polypeptide (NTCP) is encoded by the SLC10A1 (solute carrier family 10 member 1) gene and predominantly expressed on the sinusoidal membrane of hepatocytes with the function of hepatic uptake of bile salt, steroid hormones, thyroid hormones, and various bile acidconjugated drugs. Almost ten years ago, NTCP was identified as a functional cellular entry receptor of hepatitis B and hepatitis D virus (HBV/HDV), which are among the major etiological factors leading to cirrhosis, liver failure, and hepatocellular carcinoma, and affect around 250 million people worldwide.
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