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On the cover: The rising in the popularity of big data, artificial intelligence, and simulation technologies has opened up new opportunities for the development of our society. The close integration of real and artificial societies has become a trend, bringing in novel concepts such as parallel society and metaverse. The artificial society system describes, predicts, and guides the real society system, in a closed-loop, iterative, and spiral-rising way, forming a new mode of social operation driven by Data-AI-Simulation techniques. In the future, with the further development of interdisciplinary cooperation and the continuous advancement of technologies, living in metaverse is within reach. |
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Position: Home > issue > September 13, 2022 Volume 3, Issue 5 |
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From monogenic lupus to TLR7/MyD88-targeted therapy |
Category: Commentary Download: PDF Figure Endnote |
Author: Min Wang, Yezi Peng, Hao Li, Xuan Zhang |
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The role of TLR7 in SLE pathogenesis
Systemic lupus erythematosus (SLE) is a complicated autoimmune disease with multiple organ involvement and characterized by excessive autoantibody production and immune complex deposition. According to the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR) classifications of SLE, clinical manifestations and immunological indicators are two major criteria for lupus classification. A seven-year-old patient presented by Brown et al. exhibited thrombocytopenia, hypocomplementemia, and elevated autoantibodies, which are critical serological features of lupus. 1 Moreover, damage to diverse tissues including joints, kidneys, and neurological systems was observed. Altogether, this patient was diagnosed with pediatric lupus. Additionally, this individual responded well to current SLE therapies including prednisone, azathioprine, mycophenolate, and rituximab.

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