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Position: Home > issue > September 13, 2022 Volume 3, Issue 5
Multi-omic analyses identify mucosa bacteria and fecal metabolites associated with weight loss after fecal microbiota transplantation
Category:   Report   Download:  PDF  Figure  Endnote
Author: Fen Zhang, Tao Zuo, Yating Wan, Zhilu Xu, Chunpan Cheung, Amy Y. Li, Wenyi Zhu, Whitney Tang, Paul K.S. Chan, Francis K.L. Chan, Siew C. Ng

52.jpg

Graphical abstract


Fecal microbiota transplantation (FMT) has shown promising results in animal models of obesity, while results in human studies are inconsistent. We aimed to determine factors associated with weight loss after FMT in nine obese subjects using serial multi-omics analysis of the fecal and mucosal microbiome. The mucosal microbiome, fecal microbiome, and fecal metabolome showed individual clustering in each subject after FMT. The colonic microbiome in patients showed more marked variance after FMT compared with the duodenal microbiome, characterized by an increased relative abundance of Bacteroides.





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