|
 |
| On the cover: The sun not only breeds all life, but also brings inexhaustible clean energy to the earth. The development of flexible photovoltaic technology, represented by flexible perovskite solar cells, frees the energy production from the constraints of traditional centralized photovoltaic application scenarios. From spacecraft and curved photovoltaics to wearable devices and IoT sensors, the combination of flexible photovoltaics and advanced technology will realize a more flexible, convenient and imaginative collection and utilization of solar energy, contributing to a more intelligent and sustainable human society. |
|
|
| Add comment (English only) |
|
|
|
|
|
| Position: Home > issue > November 08, 2022 Volume 3, Issue 6 |
|
|
|
| A neutralizing-protective supersite of human monoclonal antibodies for yellow fever virus |
Category: Article Download:  PDF  Figure  Endnote |
| Author: Yan Li, Zhihai Chen, Lili Wu, Lianpan Dai, Jianxun Qi, Yan Chai, Shihua Li, Qihui Wang, Zhou Tong, Sufang Ma, Xiaomin Duan, Shuning Ren, Rui Song, Mifang Liang, Wenjun Liu, Jinghua Yan, George F. Gao |
|
|
Graphical abstract
The yellow fever virus (YFV) is a life-threatening human pathogen. Owing to the lack of available therapeutics, non-vaccinated individuals are at risk. Here, we isolated eight human monoclonal antibodies that neutralize YFV infection. Five recognized overlapping epitopes and exhibited potent neutralizing activity. Two (YD6 and YD73) were ultra-potent and conferred complete protection against the lethal challenge of YFV as both prophylactics and therapeutics in a mouse model. Crystal structures revealed that YD6 engaged the YFV envelope protein in both pre- and post-fusion states, suggesting viral inhibition by a "double lock" mechanism.
|
|
|
|
TheInnovation´´ÐÂ
TheInnovation´´ÐÂ
The_Innovation
office@the-innovation.org
Official£º