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Position: Home > issue > November 08, 2022 Volume 3, Issue 6
Direct evidence of CRISPR-Cas9-mediated mitochondrial genome editing
Category:   Article   Download:  PDF  Figure  Endnote
Author: Rui Bi, Yu Li, Min Xu, Quanzhen Zheng, Deng-Feng Zhang, Xiao Li, Guolan Ma, Bolin Xiang, Xiaojia Zhu, Hui Zhao, Xingxu Huang, Ping Zheng, Yong-Gang Yao

62.jpg

Graphical abstract

Pathogenic mitochondrial DNA (mtDNA) mutations can cause a variety of human diseases. The recent development of genome-editing technologies to manipulate mtDNA, such as mitochondria-targeted DNA nucleases and base editors, offer a promising way for curing mitochondrial diseases caused by mtDNA mutations. The CRISPR-Cas9 system is a widely used tool for genome editing; however, its application in mtDNA editing is still under debate. In this study, we developed a mito-Cas9 system by adding the mitochondria-targeted sequences and 3' untranslated region of nuclear-encoded mitochondrial genes upstream and downstream of the Cas9 gene, respectively.





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