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| On the cover: In recent years, driven by the new round of scientific and technological revolution, the transportation industry is undergoing unprecedented and significant changes. Emerging transport vehicles include autonomous vehicle and flying car. Some innovative operational modes appear, like Mobility as a Service and shared mobility. Meanwhile, advanced informatics technology, such as Artificial Intelligence and the Internet of Things, is also joining the way to make a better traffic. All of the progress has facilitated the emergence of Advanced Urban Aerial Mobility, a new paradigm for future transportation. The system is based on providing high-quality services as its core and the principles of energy-saving and environmental protection, making urban travel more enjoyable. This common scene in science fiction is no longer far-reaching. |
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| Position: Home > issue > Jan 30, 2023 Volume 4, Issue 2 |
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| Echinacea purpurea-derived homogeneous polysaccharide exerts anti-tumor efficacy via facilitating M1 macrophage polarization |
Category: Report Download:  PDF  Figure  Endnote |
| Author: Wenkai Ren, Junfeng Ban, Yaoyao Xia, Fang Zhou, Caihong Yuan, Huanhuan Jia, Hailan Huang, Mingmin Jiang, Minjian Liang, Zhaodong Li, Youyong Yuan, Yulong Yin, Hong Wu |
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GRAPHICAL ABSTRACT
Echinacea purpurea modulates tumor progression, but the underlying mechanism is poorly defined. We isolated and purified a novel homogeneous polysaccharide from E. purpurea (EPPA), which was shown to be an arabinogalactan with a mean molecular mass (Mr) of 3.8 ¡Á 104 Da and with ¦Á- (1 ¡ú 5) -L-Arabinan as the backbone and ¦Á-L-Araf-(1¡ú, ¡ú6)-¦Â-D-Galp-(1¡ú, and ¡ú4)-¦Á-D-GalpA-(1¡ú as the side chains. Interestingly, oral administration of EPPA suppresses tumor progression in vivo and shapes the immune cell profile (e.g., facilitating M1 macrophages) in tumor microenvironment by single-cell RNA sequencing (scRNA-seq) analysis.
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