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| On the cover: In recent years, driven by the new round of scientific and technological revolution coupled with carbon neutrality, the energy structure is undergoing unprecedented changes. Biomass energy can be obtained from abundant resources by a number of application ways, which is zero-carbon and has unique effect of carbon negative emission. Meanwhile, advanced conversion technologies, such as BECCS, pyrolysis, and biohydrogen, are also joining the way to make a better bioenergy. Clean products of biomass have been promoted to a prospective future. Combination of biomass energy development and advanced technology will realize a more flexible and imaginative use of biomass, contributing to a green, low-carbon and sustainable development. For a bright and recyclable future, we should improve the use of biomass energy and unlock its huge potential for energy conservation and carbon reduction. |
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| Position: Home > issue > May 15, 2023 Volume 4, Issue 3 |
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| Novel microfluidic device for measurable residual disease detection in acute leukemia |
Category: Translational Patent Download:  PDF  Figure  Endnote |
| Author: Ziwei Cai, Shuang Fan, Xiaoyi Sun, Xiaodong Mo, Gen Yang |
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Principle and methodology of utilizing CTC enrichment chips in MRD detection
Relapse is the most important cause of treatment failure in acute leukemia (AL). Thus, how to predict relapse is critical for improving the survival of patients with AL. Measurable residual diseases (MRDs; previously termed minimal residual diseases), referring to the presence of remaining leukemia cells after the declaration of complete remission (CR) detected by morphological analysis, is the most important biomarker for relapse prediction.1 Several methods, including multiparameter flow cytometry (MFC), real-time quantitative polymerase chain reaction (qPCR), digital PCR (dPCR), and next-generation sequencing (NGS), are used to monitor MRD after treatment, reaching a sensitivity of 10−4 to 10−6.
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