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| On the cover: In recent years, driven by the new round of scientific and technological revolution coupled with carbon neutrality, the energy structure is undergoing unprecedented changes. Biomass energy can be obtained from abundant resources by a number of application ways, which is zero-carbon and has unique effect of carbon negative emission. Meanwhile, advanced conversion technologies, such as BECCS, pyrolysis, and biohydrogen, are also joining the way to make a better bioenergy. Clean products of biomass have been promoted to a prospective future. Combination of biomass energy development and advanced technology will realize a more flexible and imaginative use of biomass, contributing to a green, low-carbon and sustainable development. For a bright and recyclable future, we should improve the use of biomass energy and unlock its huge potential for energy conservation and carbon reduction. |
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| Position: Home > issue > May 15, 2023 Volume 4, Issue 3 |
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| Targeted protein degradation in cancers: Orthodox PROTACs and beyond |
Category: Review Download:  PDF  Figure  Endnote |
| Author: Jin Li, Xinxin Chen, Aiping Lu, Chao Liang |
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GRAPHICAL ABSTRACT
Targeted protein degradation (TPD) is emerging as a strategy to overcome the limitations of traditional small-molecule inhibitors. Proteolysis-targeting chimera (PROTAC) technology can be used to target proteins by hijacking the ubiquitin-proteasome system. Conceptually, PROTAC aims to target the ¡°undruggable¡± majority of proteins in the human proteome. Through constant exploration and optimization of PROTACs and the exploitation of other TPD strategies over two decades, TPD has expanded from theoretical studies to clinical strategies, with practical applications in oncological, immunological, and other diseases.
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