RXR signaling targeted cancer therapy

Wenrui Zhao; Suyao Li; Ruoxue Chen; Junjie Ni; Xuan Huang; Song Li; Xiaoling Lu; Xin Cao

doi:10.59717/j.xinn-life.2023.100014

The Innovation Life > 2023 Vol. 1 > No. 1 > 100014

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RXR signaling targeted cancer therapy

1.
Zhongshan Hospital Institute of Clinical Science, Fudan University Shanghai Medical College, 180 Fenglin Road, Shanghai 200032, China
2.
Department of Medical Oncology, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai 200032, China
3.
College of Basic Medical Sciences, Department of Biochemistry and Molecular Biology, Naval Medical University, Shanghai 200433, China
4.
These authors contributed equally to this work.

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Corresponding authors: luxiaoling80@126.com (X. L.); caox@fudan.edu.cn (X. C.)
Received Date: 03 March 2023

Accepted Date: 12 May 2023

Published Online: 02 June 2023

The Innovation Life 1(1), https://doi.org/10.59717/j.xinn-life.2023.100014 | Cite this article

GRAPHICAL ABSTRACT

GRAPHICAL ABSTRACT

PUBLIC SUMMARY

PUBLIC SUMMARY
1. Retinoic X receptors (RXRs) are important nuclear receptors mediating genetic transcriptions.
  
  Review the comprehensive role of RXR between RXR signaling and oncogenesis.
  
  Summarize the undervalued rexinoid-related cancer therapy.
  
  Discuss and propose its great potential in future clinics.

ABSTRACT

ABSTRACT

Retinoic X receptor (RXR) acts as a critical player in regulating a series of genetic transcriptions in cancer cells since it heterodimerizes with a third of nuclear receptors (NRs). However, RXR-targeted cancer therapy was greatly undervalued. Bexarotene (Targretin®) was the first synthetic rexinoid that was approved by Food and Drug Administration for refractory cutaneous T-cell lymphoma treatment in 2000. Afterward, researchers started to focus more on the function of RXR and modifications of RXR, such as phosphorylated-RXRα (p-RXRα) and truncated RXRα (tRXRα). Meanwhile, RXR-modulating drugs began to attract more interest from oncologists because of their potential in interfering with cancer cell proliferation, differentiation, and apoptosis according to the important and comprehensive regulation effects of RXR in tumorigenesis.
Herein, we will review the comprehensive role of RXR between RXR signaling and oncogenesis, with a highlighted focus on the undervalued rexinoid-related cancer therapy, and discuss and propose its great potential in future clinics.

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Zhao W., Li S., Chen R., et al., (2023). RXR signaling targeted cancer therapy. The Innovation Life 1(1), 100014. https://doi.org/10.59717/j.xinn-life.2023.100014

Zhao W., Li S., Chen R., et al., (2023). RXR signaling targeted cancer therapy. The Innovation Life 1(1), 100014. https://doi.org/10.59717/j.xinn-life.2023.100014

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