Landscape of human organoids: Ideal model in clinics and research

Xinxin Han; Chunhui Cai; Wei Deng; Yanghua Shi; Lanyang Li; Chen Wang; Jian Zhang; Mingjie Rong; Jiping Liu; Bangjiang Fang; Hua He; Xiling Liu; Chuxia Deng; Xiao He; Xin Cao

doi:10.1016/j.xinn.2024.100620

The Innovation > 2024 Vol. 5 > No. 3

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Landscape of human organoids: Ideal model in clinics and research

1.
Organ Regeneration X Lab, Lisheng East China Institute of Biotechnology, Peking University, Jiangsu 226200, China
2.
Shanghai Lisheng Biotech, Shanghai 200092, China
3.
LongHua Hospital, Shanghai University of Traditional Chinese Medicine, 725 Wanping South Road, Xuhui District, Shanghai 200032, China
4.
Department of Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China
5.
Department of Neurosurgery, Third Affiliated Hospital, Naval Medical University, Shanghai 200438, China
6.
Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Ministry of Justice, Shanghai 200063, China
7.
Cancer Center, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China
8.
Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macau SAR 999078, China
9.
CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China
10.
Zhongshan Hospital Institute of Clinical Science, Fudan University Shanghai Medical College, Shanghai 200032, China

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¹¹ These authors contributed equally
Corresponding authors: xxhan@sibs.ac.cn (X.H.); cxdeng@um.edu.mo (C.D.); hexiao@ihep.ac.cn (X.H.); caox@fudan.edu.cn (X.C.)
Received Date: October 31, 2023

Accepted Date: March 29, 2024

Published Online: April 01, 2024

The Innovation 5(3), https://doi.org/10.1016/j.xinn.2024.100620 | Cite this article

GRAPHICAL ABSTRACT

GRAPHICAL ABSTRACT

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PUBLIC SUMMARY

PUBLIC SUMMARY
1. ■ The landscape of organoids history: organoids mark a new and efficient model in tissue and organ level.
2. ■ Multiple applications of organoids in biomedicine and life healthcare.
3. ■ Organoids benefit to drug discovery, disease study, prevention, control, and therapy.
4. ■ Synthetic biology, artificial intelligence and automation integration broaden the role of organoids.

ABSTRACT

ABSTRACT

In the last decade, organoid research has entered a golden era, signifying a pivotal shift in the biomedical landscape. The year 2023 marked a milestone with the publication of thousands of papers in this arena, reflecting exponential growth. However, amid this burgeoning expansion, a comprehensive and accurate overview of the field has been conspicuously absent. Our review is intended to bridge this gap, providing a panoramic view of the rapidly evolving organoid landscape. We meticulously analyze the organoid field from eight distinctive vantage points, harnessing our rich experience in academic research, industrial application, and clinical practice. We present a deep exploration of the advances in organoid technology, underpinned by our long-standing involvement in this arena. Our narrative traverses the historical genesis of organoids and their transformative impact across various biomedical sectors, including oncology, toxicology, and drug development. We delve into the synergy between organoids and avant-garde technologies such as synthetic biology and single-cell omics and discuss their pivotal role in tailoring personalized medicine, enhancing high-throughput drug screening, and constructing physiologically pertinent disease models. Our comprehensive analysis and reflective discourse provide a deep dive into the existing landscape and emerging trends in organoid technology. We spotlight technological innovations, methodological evolution, and the broadening spectrum of applications, emphasizing the revolutionary influence of organoids in personalized medicine, oncology, drug discovery, and other fields. Looking ahead, we cautiously anticipate future developments in the field of organoid research, especially its potential implications for personalized patient care, new avenues of drug discovery, and clinical research. We trust that our comprehensive review will be an asset for researchers, clinicians, and patients with keen interest in personalized medical strategies. We offer a broad view of the present and prospective capabilities of organoid technology, encompassing a wide range of current and future applications. In summary, in this review we attempt a comprehensive exploration of the organoid field. We offer reflections, summaries, and projections that might be useful for current researchers and clinicians, and we hope to contribute to shaping the evolving trajectory of this dynamic and rapidly advancing field.

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Han X., Cai C., Deng W., et al., (2024). Landscape of human organoids: Ideal model in clinics and research. The Innovation 5(3), 100620. https://doi.org/10.1016/j.xinn.2024.100620

Han X., Cai C., Deng W., et al., (2024). Landscape of human organoids: Ideal model in clinics and research. The Innovation 5(3), 100620. https://doi.org/10.1016/j.xinn.2024.100620

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