Terahertz technology: A new frontier in Alzheimer’s disease therapy

Jun Zhang; Cong Liu; Junhong Lü; Ruixue Xu; Weidong Le

doi:10.59717/j.xinn-life.2024.100084

The Innovation Life > 2024 Vol. 2 > No. 3 > 100084

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Terahertz technology: A new frontier in Alzheimer’s disease therapy

1.
Liaoning Provincial Center for Clinical Research on Neurological Diseases, the First Affiliated Hospital of Dalian Medical University, Dalian 116024, China
2.
Department of Neurology, the Affiliated Xinhua Hospital, Dalian University, Dalian 116024, China
3.
Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 201210, China
4.
Phenomics & Healthspan Pharmacology Lab, School of Pharmacy, Binzhou Medical University, Yantai 264003, China
5.
Department of Neurosurgery, the First Affiliated Hospital of Dalian Medical University, Dalian 116024, China
6.
Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai 201318, China

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Corresponding authors: wdle_sibs@163.com (W.L.); xrx1976@163.com (R.X.)
Received Date: June 24, 2024

Accepted Date: August 02, 2024

Published Online: August 21, 2024

The Innovation Life 2(3), https://doi.org/10.59717/j.xinn-life.2024.100084 | Cite this article

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GRAPHICAL ABSTRACT

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PUBLIC SUMMARY

PUBLIC SUMMARY
1. Summarize the neurobiological effects of Terahertz (THz) waves on the pathology of AD.
  
  Discuss the biological mechanism and molecular basis of THz therapy on AD.
  
  Introduce the application and biosafety of THz technology in neuroscience.

ABSTRACT

ABSTRACT

The vibrational and rotational energy levels of many biomacromolecules fall within the Terahertz (THz) frequency range, indicating that THz waves, under specific conditions, can interact with and affect the structure and functionality of various biological systems, including the brain. Increasing evidence suggests that the overproduction or inadequate elimination of amyloid beta (Aβ), leading to the accumulation of senile plaques (SPs) in the brain, is a key factor in the development of Alzheimer's disease (AD). The AD-affected brain exhibits several pathological hallmarks, such as hyperphosphorylation of tau protein, which leads to the formation of neurofibrillary tangles (NFTs), neuroinflammation, and degeneration of neurites and synapses. All of these may play important roles in the onset and progression of the disease. Current research primarily focuses on utilizing THz technology for biomonitoring and imaging, with less exploration into the biological effects of THz irradiation on AD. This review aims to examine the neurobiological effects of THz irradiation on AD pathology, including its impacts on neurons, mitochondria, blood vessels, and inflammation, and to provide an update on the current status of THz technology research in AD. It is designed to provide a new perspective for researchers in neuroscience, THz technology, and biomedicine.

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Zhang J., Liu C., Lü J., et al., (2024). Terahertz technology: A new frontier in Alzheimer’s disease therapy. The Innovation Life 2(3): 100084. https://doi.org/10.59717/j.xinn-life.2024.100084

Zhang J., Liu C., Lü J., et al., (2024). Terahertz technology: A new frontier in Alzheimer’s disease therapy. The Innovation Life 2(3): 100084. https://doi.org/10.59717/j.xinn-life.2024.100084

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