Two-dimensional nanomaterials for inflammation-related disease treatments

Ya-Xuan Zhu; Linlin Lei; Zhiqiang Zhang; Zhixin Chen; Han Lin; Jianlin Shi

doi:10.59717/j.xinn-mater.2025.100128

The Innovation Materials > 2025 Vol. 3 > No. 2 > 100128

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Two-dimensional nanomaterials for inflammation-related disease treatments

1.
Shanghai Tenth People's Hospital, Shanghai Frontiers Science Center of Nanocatalytic Medicine, School of Medicine, Tongji University, Shanghai 200331, China
2.
State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences; Research Unit of Nanocatalytic Medicine in Specific Therapy for Serious Disease, Chinese Academy of Medical Sciences (2021RU012), Shanghai 200050, China
3.
Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China

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Corresponding authors: linhan@mail.sic.ac.cn (H.L.); jlshi@mail.sic.ac.cn (J.S.)
Received Date: December 16, 2024

Accepted Date: March 31, 2025

Published Online: April 03, 2025

The Innovation Materials 3(2), https://doi.org/10.59717/j.xinn-mater.2025.100128 | Cite this article

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GRAPHICAL ABSTRACT

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PUBLIC SUMMARY

PUBLIC SUMMARY
1. Categorizing the regulatory mechanisms of 2D nanomaterials toward inflammation.
  
  Highlighting the advantages of 2D nanomaterials in anti-inflammatory applications.
  
  Summarizing the therapeutic applications of 2D nanomaterials in inflammation-related diseases.

ABSTRACT

ABSTRACT

Two-dimensional (2D) nanomaterials are an emerging class of materials with sheet-like morphology, open and flat lateral surface, and atomic thickness, presenting unique properties over other nanomaterials, such as extra-large surface area, compelling electronic properties, easy surface modification, and good mechanical strength. In recent years, 2D nanomaterials have emerged as versatile platforms for modulating inflammatory pathways, offering novel mechanisms to complement conventional anti-inflammatory therapies. Their unique physiochemical properties enable precise intervention in pathological processes through three distinct modalities: (i) eliminating pathogen invasion and infection through their morphology, photothermal, or catalytic effects to temper inflammation; (ii) serving as antioxidants or catalysts to scavenge excessive reactive oxygen species generated during inflammatory responses; (iii) delivering therapeutic agents, such as anti-inflammation drugs or therapeutic gases, to synergistically regulate inflammatory responses. In this review, we first introduce the biological process of inflammatory responses and their relationship to diseases; next the mechanism of 2D nanomaterials for inflammation regulation will be discussed; and finally, the recent applications of 2D nanomaterials for the treatments of inflammation-related disease will be presented and summarized. It is expected that this review may inspire the rational designs and constructions of next generation 2D material-based functional systems for inflammation-related disease treatments.

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Zhu Y., Lei L., Zhang Z., et al. (2025). Two-dimensional nanomaterials for inflammation-related disease treatments. The Innovation Materials 3:100128. https://doi.org/10.59717/j.xinn-mater.2025.100128

Zhu Y., Lei L., Zhang Z., et al. (2025). Two-dimensional nanomaterials for inflammation-related disease treatments. The Innovation Materials 3:100128. https://doi.org/10.59717/j.xinn-mater.2025.100128

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Two-dimensional nanomaterials for inflammation-related disease treatments

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