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The Innovation Medicine > 2025 Vol. 3 > No. 1 > 100119
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Chimeric Antigen Receptor T-cell therapy in pediatric refractory systemic lupus erythematosus

  • 1.

    Department of Nephrology, Children’s Hospital, Zhejiang University School of Medicine, National clinical research center for child health, Hangzhou 310052, China

  • 2.

    Department of Allergy Immunology and Rheumatology, Children’s Hospital, Zhejiang University School of Medicine, National clinical research center for child health, Hangzhou 310052, China

  • 3.

    Chongqing Precision Biotech Co., Ltd., Chongqing 400039, China

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  • Corresponding author: maojh88@zju.edu.cn
  • Received Date:  December 15, 2024
    Accepted Date:  February 19, 2025
    Published Online:  February 21, 2025
The Innovation Medicine  3(1),  https://doi.org/10.59717/j.xinn-med.2025.100119  |  Cite this article
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    • REFERENCES
  • [1] Charras A., Smith E. and Hedrich C. M. (2021). Systemic lupus erythematosus in children and young people. Curr. Rheumatol. Rep. 23:20 DOI:10.1007/s11926-021-00985-0

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    [2] Mougiakakos D., Krönke G., Völkl S., et al. (2021). CD19-targeted CAR T cells in refractory systemic lupus erythematosus. N. Engl. J. Med. 385:567−569 DOI:10.1056/NEJMc2107725

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    [3] Schett G., Müller F., Taubmann J., et al. (2024). Advancements and challenges in CAR T cell therapy in autoimmune diseases. Nat. Rev. Rheumatol. 20:531−544 DOI:10.1038/s41584-024-01139-z

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    [4] Atisha-Fregoso Y., Malkiel S., Harris K. M., et al. (2021). Phase II randomized trial of rituximab plus cyclophosphamide followed by Belimumab for the treatment of lupus nephritis. Arthritis Rheumatol. 73:121−131 DOI:10.1002/art.41466

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    [5] He X., Hu B., Zhang Y., et al. (2025). Treatment of two pediatric patients with refractory systemic lupus erythematosus using CD19-targeted CAR T-cells. Autoimmun. Rev. 24:103692 DOI:10.1016/j.autrev.2024.103692

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  • Cite this article:

    He X., Liu F., Lu M., et al. (2025). Chimeric Antigen Receptor T-cell therapy in pediatric refractory systemic lupus erythematosus. The Innovation Medicine 3:100119. https://doi.org/10.59717/j.xinn-med.2025.100119
    He X., Liu F., Lu M., et al. (2025). Chimeric Antigen Receptor T-cell therapy in pediatric refractory systemic lupus erythematosus. The Innovation Medicine 3:100119. https://doi.org/10.59717/j.xinn-med.2025.100119

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