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The Innovation Medicine > 2025 Vol. 3 > No. 4 > 100162
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Environmental pollutants cause placental dysfunctions to induce miscarriage

  • 1.

    Research Center for Environment and Female Reproductive Health, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen 518033, China

  • 2.

    Medical Research Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou 510080, China

  • 3.

    MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan 030001, China

  • 4.

    Department of Emergency; Cerebrovascular disease center, First Hospital of Shanxi Medical University, Taiyuan 030001, China

  • 5.

    These authors contributed equally

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The Innovation Medicine  3(4),  https://doi.org/10.59717/j.xinn-med.2025.100162  |  Cite this article
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    • REFERENCES
  • [1] Practice Committee of the American Society for Reproductive Medicine. (2012). Evaluation and treatment of recurrent pregnancy loss: A committee opinion. Fertil. Steril. 98:1103−1111. DOI:10.1016/j.fertnstert.2012.06.048

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    [2] Chen W., Mi C., Zhang Y., et al. (2024). Defective homologous recombination repair by up-regulating Lnc-HZ10/Ahr loop in human trophoblast cells induced miscarriage. Adv. Sci. 11:e2207435. DOI:10.1002/advs.202207435

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    [3] Zhao J., Xu Z., Xie J., et al. (2024). The novel lnc-HZ12 suppresses autophagy degradation of BBC3 by preventing its interactions with HSPA8 to induce trophoblast cell apoptosis. Autophagy 20:2255−2274. DOI:10.1080/15548627.2024.2362122

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    [4] Wan S., Wang X., Chen W., et al. (2024). Polystyrene nanoplastics activate autophagy and suppress trophoblast cell migration/invasion and migrasome formation to induce miscarriage. ACS Nano 18:3733−3751. DOI:10.1021/acsnano.3c11734

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    [5] Tian P., Xu Z., Guo J., et al. (2024). Hypoxia causes trophoblast cell ferroptosis to induce miscarriage through lnc-HZ06/HIF1α-SUMO/NCOA4 axis. Redox Biol. 70:103073. DOI:10.1016/j.redox.2024.103073

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  • Cite this article:

    Sun Y., Huang W., Sun L., et al. (2025). Environmental pollutants cause placental dysfunctions to induce miscarriage. The Innovation Medicine 3:100162. https://doi.org/10.59717/j.xinn-med.2025.100162
    Sun Y., Huang W., Sun L., et al. (2025). Environmental pollutants cause placental dysfunctions to induce miscarriage. The Innovation Medicine 3:100162. https://doi.org/10.59717/j.xinn-med.2025.100162

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