Peroxisomes countering long-COVID: The anti-inflammatory organelles of alveolar macrophages halt chronic viral diseases
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Jia P., Cao J., Wu M., et al. (2025). Peroxisomes countering long-COVID: The anti-inflammatory organelles of alveolar macrophages halt chronic viral diseases. The Innovation Medicine 3:100169. https://doi.org/10.59717/j.xinn-med.2025.100169
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Jia P., Cao J., Wu M., et al. (2025). Peroxisomes countering long-COVID: The anti-inflammatory organelles of alveolar macrophages halt chronic viral diseases. The Innovation Medicine 3:100169. https://doi.org/10.59717/j.xinn-med.2025.100169
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Figure 1.
(A) Model of peroxisome function in macrophage-mediated alveolar regeneration after viral injury. Peroxisome activity in alveolar macrophages (AM) is essential for AT2 self-renewal and alveolar repair following viral infection. Dysfunction of macrophage peroxisomes causes excessive inflammasome activation and KRT8high accumulation, resulting in a chronic tissue sequelae post acute infection. Critically, 4-PBA treatment facilitates peroxisome biogenesis in macrophages and enhancing alveolar regeneration after respiratory viral infection. (B) Analysis of lung tissues from COVID-19 patients and in mice of severe infection models revealed reduced peroxisome numbers and structural abnormalities in macrophages. In Pex5ΔCd11c mice (with AM specific deficiency), impaired alveolar regeneration, accumulation of KRT8high, and fibrosis occur.
