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The Innovation Medicine > 2026 Vol. 4 > No. 2 > 100198
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Breaking undruggable: The emergence of KRASG12D targeted therapy

  • 1.

    Endoscopy Center, Department of Gastroenterology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai 200120, China

  • 2.

    Institute of Clinical Science, Zhongshan Hospital, Fudan University, Shanghai 200032, China

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  • Corresponding author: caox@fudan.edu.cn
  • Received Date:  November 29, 2025
    Accepted Date:  February 03, 2026
    Published Online:  February 04, 2026
The Innovation Medicine  4(2),  https://doi.org/10.59717/j.xinn-med.2026.100198  |  Cite this article
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    • REFERENCES
  • [1] Yoshinari T., Nagashima T., Ishioka H., et al. (2025). Discovery of KRAS(G12D) selective degrader ASP3082. Commun. Chem. 8:254. DOI:10.1038/s42004-025-01662-4

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    [2] Khan N., Raza U., Ali Zaidi S.A., et al. (2025). Drugging the 'undruggable' KRAS: Breakthroughs, challenges, and opportunities in pancreatic cancer. Cancer Biol. Med. 22:762−788. DOI:10.20892/j.issn.2095-3941.2025.0122

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    [3] Miyamoto-Sato E., Imanishi S., Huang L., et al. (2023). A first-class degrader candidate targeting both KRAS G12D and G12V mediated by CANDDY technology independent of ubiquitination. Molecules 28:5600. DOI:10.3390/molecules28145600

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    [4] Nalawansha D.A., Mazis G., Husemoen G., et al. (2025). LYMTACs: Chimeric small molecules repurpose lysosomal membrane proteins for target protein relocalization and degradation. Nat. Commun. 16:7812. DOI:10.1038/s41467-025-63128-4

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    [5] Ghazi Vakili M., Gorgulla C., Snider J., et al. (2025). Quantum-computing-enhanced algorithm unveils potential KRAS inhibitors. Nat. Biotechnol. 43:1954−1959. DOI:10.1038/s41587-024-02526-3

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  • Cite this article:

    Du X. and Cao X. (2026). Breaking undruggable: The emergence of KRASG12D targeted therapy. The Innovation Medicine 4:100198. https://doi.org/10.59717/j.xinn-med.2026.100198
    Du X. and Cao X. (2026). Breaking undruggable: The emergence of KRASG12D targeted therapy. The Innovation Medicine 4:100198. https://doi.org/10.59717/j.xinn-med.2026.100198

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