Microbiota-derived UDP-galactose links dietary protein restriction to antitumor immunity in pancreatic cancer
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REFERENCES
[1] Chen Y., Nian F., Wu S., et al. (2026). Low-protein diet enhances antitumor immunity in pancreatic cancer through microbiota-derived UDP-galactose. Nat. Cancer Published online August 17, 2026. DOI:10.1038/s43018-026-01222-2. [2] Mirji G., Worth A., Bhat S. A., et al. (2022). The microbiome-derived metabolite TMAO drives immune activation and boosts responses to immune checkpoint blockade in pancreatic cancer. Sci. Immunol. 7:eabn0704. DOI:10.1126/sciimmunol.abn0704 [3] Tintelnot J., Xu Y., Lesker T. R., et al. (2023). Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer. Nature 615:168−174. DOI:10.1038/s41586-023-05728-y [4] Scolaro T., Manco M., Pecqueux M., et al. (2024). Nucleotide metabolism in cancer cells fuels a UDP-driven macrophage cross-talk, promoting immunosuppression and immunotherapy resistance. Nat. Cancer 5:1206−1226. DOI:10.1038/s43018-024-00771-8 [5] Zhang X., Li S., Malik I., et al. (2023). Reprogramming tumour-associated macrophages to outcompete cancer cells. Nature 619:616−623. DOI:10.1038/s41586-023-06256-5 -
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Wei Z. (2026). Microbiota-derived UDP-galactose links dietary protein restriction to antitumor immunity in pancreatic cancer. The Innovation Nutrition 1:100043. https://doi.org/10.59717/j.xinn-nutri.2026.100043
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Wei Z. (2026). Microbiota-derived UDP-galactose links dietary protein restriction to antitumor immunity in pancreatic cancer. The Innovation Nutrition 1:100043. https://doi.org/10.59717/j.xinn-nutri.2026.100043
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Figure 1.
Schematic presentation of the proposed model in the Chen et. al. study.
