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The Innovation Informatics > 2026 Vol. 2 > No. 2 > 100043
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Language brain-computer interfaces: Toward clinically scalable speech neuroprosthesis

  • 1.

    Research Center for Medical AI, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China

  • 2.

    Key Laboratory of Biomedical Imaging Science and System, Chinese Academy of Sciences, Shenzhen 518055, China

  • 3.

    Lab of Molecular Imaging and Medical Intelligence, Department of Radiology, Longgang Central Hospital of Shenzhen, Shenzhen 518116, China

  • 4.

    Shenzhen Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen 518116, China

  • 5.

    Longgang Clinical Institute of Shantou University Medical College, Shenzhen 518116, China

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  • Corresponding author: zl.hu@siat.ac.cn
  • Received Date:  January 23, 2026
    Accepted Date:  April 03, 2026
    Published Online:  April 17, 2026
The Innovation Informatics  2(2),  https://doi.org/10.59717/j.xinn-inform.2026.100043  |  Cite this article
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    • REFERENCES
  • [1] Silva A.B., Littlejohn K.T., Liu J.R., et al. (2024). The speech neuroprosthesis. Nat. Rev. Neurosci. 25:473−492. DOI:10.1038/s41583-024-00819-9

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    [2] Card N.S., Wairagkar M., Iacobacci C., et al. (2024). An accurate and rapidly calibrating speech neuroprosthesis. N. Engl. J. Med. 391:609−618. DOI:10.1056/NEJMoa2314132

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    [3] Littlejohn K.T., Cho C.J., Liu J.R., et al. (2025). A streaming brain-to-voice neuroprosthesis to restore naturalistic communication. Nat. Neurosci. 28:902−912. DOI:10.1038/s41593-025-01905-6

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    [4] Kunz E.M., Abramovich Krasa B., Kamdar F., et al. (2025). Inner speech in motor cortex and implications for speech neuroprostheses. Cell 188:4658−4673. DOI:10.1016/j.cell.2025.06.015

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    [5] Qian Y., Liu C., Yu P., et al. (2025). Real-time decoding of full-spectrum Chinese using brain-computer interface. Sci. Adv. 11:eadz9968. DOI:10.1126/sciadv.adz9968

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  • Cite this article:

    Guo W., Jiang H., Liu H., et al. (2026). Language brain-computer interfaces: Toward clinically scalable speech neuroprosthesis. The Innovation Informatics 2:100043. https://doi.org/10.59717/j.xinn-inform.2026.100043
    Guo W., Jiang H., Liu H., et al. (2026). Language brain-computer interfaces: Toward clinically scalable speech neuroprosthesis. The Innovation Informatics 2:100043. https://doi.org/10.59717/j.xinn-inform.2026.100043

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