Metabolic collaboration between cells in the tumor microenvironment has a negligible effect on tumor growth

Johan Gustafsson; Fariba Roshanzamir; Anders Hagnestål; Sagar M. Patel; Oseeyi I. Daudu; Donald F. Becker; Jonathan L. Robinson; Jens Nielsen

doi:10.1016/j.xinn.2024.100583

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Metabolic collaboration between cells in the tumor microenvironment has a negligible effect on tumor growth

1.
Department of Life Sciences, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden
2.
Hagnesia AB, SE-43854 Hindås, Sweden
3.
Department of Biochemistry and Redox Biology Center, University of Nebraska-Lincoln, Lincoln, NE 68588, USA
4.
BioInnovation Institute, DK2200 Copenhagen, Denmark

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Corresponding author: nielsenj@chalmers.se
Received Date: April 28, 2023

Accepted Date: January 24, 2024

Published Online: January 30, 2024

The Innovation 5(2), https://doi.org/10.1016/j.xinn.2024.100583 | Cite this article

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1. ■ Simplified application of enzyme usage constraints to genome-scale metabolic models with the software GECKO Light.
2. ■ Estimation of maximum metabolite influx into tumors at varying levels of hypoxia.
3. ■ Simulations of tumor metabolism explain "glutamine addiction" in cancers.
4. ■ Metabolic collaboration between cell types in the tumor microenvironment does not increase tumor growth.

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Johan Gustafsson, Fariba Roshanzamir, Anders Hagnestål, Sagar M. Patel, Oseeyi I. Daudu, Donald F. Becker, Jonathan L. Robinson, Jens Nielsen. Metabolic collaboration between cells in the tumor microenvironment has a negligible effect on tumor growth[J]. The Innovation, 2024, 5(2). https://doi.org/10.1016/j.xinn.2024.100583

Johan Gustafsson, Fariba Roshanzamir, Anders Hagnestål, Sagar M. Patel, Oseeyi I. Daudu, Donald F. Becker, Jonathan L. Robinson, Jens Nielsen. Metabolic collaboration between cells in the tumor microenvironment has a negligible effect on tumor growth[J]. The Innovation, 2024, 5(2). https://doi.org/10.1016/j.xinn.2024.100583

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Metabolic collaboration between cells in the tumor microenvironment has a negligible effect on tumor growth

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