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The Innovation > 2024 Vol. 5 > No. 3
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DNA bridging of FOXP3 ladder-like multimer: Unveiling a novel transcriptional regulation paradigm

  • 1.

    Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education, Shanghai Xuhui Central Hospital and School of Basic Medical Sciences, Fudan University, Shanghai 200032, China

  • 2.

    Institute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China

  • 3.

    Center for Immune-Related Diseases at Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

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  • 4These authors contributed equally

  • Corresponding author: wangzuoyun@fudan.edu.cn
  • Received Date:  December 03, 2023
    Accepted Date:  February 27, 2024
    Published Online:  February 29, 2024
The Innovation  5(3),  https://doi.org/10.1016/j.xinn.2024.100598  |  Cite this article
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  • [1] Zhang, W., Leng, F., Wang, X., et al. (2023). FOXP3 recognizes microsatellites and bridges DNA through multimerization. Nature 624(7991): 433–441. https://doi.org/10.1038/s41586-023-06793-z.

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    [2] Lu, L., Barbi, J., and Pan, F. (2017). The regulation of immune tolerance by FOXP3. Nat. Rev. Immunol. 17(11): 703–717. https://doi.org/10.1038/nri.2017.75.

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    [3] Chen, Y., Chen, C., Zhang, Z., et al. (2015). DNA binding by FOXP3 domain-swapped dimer suggests mechanisms of long-range chromosomal interactions. Nucleic Acids Res. 43(2): 1268–1282. https://doi.org/10.1093/nar/gku1373.

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    [4] Leng, F., Zhang, W., Ramirez, R.N., et al. (2022). The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis. Immunity 55(8): 1354–1369.e8. https://doi.org/10.1016/j.immuni.2022.07.002.

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    [5] Li, B., Samanta, A., Song, X., et al. (2007). FOXP3 is a homo-oligomer and a component of a supramolecular regulatory complex disabled in the human XLAAD/IPEX autoimmune disease. Int. Immunol. 19(7): 825–835. https://doi.org/10.1093/intimm/dxm043.

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  • Cite this article:

    Lu Y., Li L., Yang H., et al., (2024). DNA bridging of FOXP3 ladder-like multimer: Unveiling a novel transcriptional regulation paradigm. The Innovation 5(3), 100598. https://doi.org/10.1016/j.xinn.2024.100598
    Lu Y., Li L., Yang H., et al., (2024). DNA bridging of FOXP3 ladder-like multimer: Unveiling a novel transcriptional regulation paradigm. The Innovation 5(3), 100598. https://doi.org/10.1016/j.xinn.2024.100598

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