Who is the Missing “Matchmaker” between Proteins and Nucleic Acids?

A new conceptual logic model showing how ATP energetically drove the origins of the genetic code and biochemical systems in the protocell based on the ATP matchmaking hypothesis

Sixty years has passed since the cracking of the genetic code by Nirenberg and Matthaei in 1961; however, the origin of the code remains one of the greatest mysteries. It is great for a cell to innovate protein synthesis manipulated by RNA, and vice versa, which is a still unsolved “chicken-and-egg” paradox. Finding a solution is of crucial importance. Yet, most biologists hold a pessimistic view that no one knows exactly how the genetic code came into being, as an exact reconstruction of the process of the construction of genetic code may never be possible, or as there is no evidence in physics or chemistry of the control of chemical reactions by a sequence of any sort or of a code between sequences, and many papers have been published with titles indicating that their subject is the origin of the genetic code, while the content actually deals only with the evolution of the genetic code.