Applications and potentials of nanopore sequencing in the (epi)genome and (epi)transcriptome era

Graphical abstract

The Human Genome Project opened an era of (epi)genomic research, and also provided a platform for the development of new sequencing technologies. During and after the project, several sequencing technologies continue to dominate nucleic acid sequencing markets. Currently, Illumina (short-read), PacBio (long-read), and Oxford Nanopore (long-read) are the most popular sequencing technologies. Unlike PacBio or the popular short-read sequencers before it, which, as examples of the second or so-called Next-Generation Sequencing platforms, need to synthesize when sequencing, nanopore technology directly sequences native DNA and RNA molecules.

DOI:
https://doi.org/10.1016/j.xinn.2021.100153

Citation:
Xie S., Leung A., Zheng Z., Zhang D., Luo R., Luo M., Zhang S. (2021). Applications and potentials of nanopore sequencing in the (epi)genome and (epi)transcriptome era. The Innovation. 2(4),100153.