Neural circuits underlying motor and non-motor defects of Parkinson' s disease
PF circuits underlying motor and mood defects of PD
Parkinson' s disease (PD) is a neurodegenerative disorder that causes unintended and uncontrollable movements, such as tremors, rigidity, and difficulty with balance and coordination. Neuronal degeneration in the basal ganglia network has been suggested as a likely cause for some PD symptoms. More specifically, such degeneration would lead to an imbalance between the direct pathway (from striatum to substantia nigra) and the indirect pathway (from striatum to pallidum), which subsequently drives movement deficits.
