Translational perspective on bone-derived cytokines in inter-organ communications

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Opportunities and challenges in translating osteokines from lab to clinic


The concept of "organic wholeness" permeates all the fields of traditional Chinese medicine, which is also widely accepted by modern medicine. The wealth of knowledge regarding inter-organ communications generated in the latest decades provided solid evidence that human physiology and pathophysiology involve systematic interactions between multiple organs or tissues. Therefore, advancing our understanding of the inter-organ communication process is believed to provide a new perspective for treating various human diseases.




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