Call for proposals: Top 100 global challenges humanity must address

What are the most critical challenges humanity must confront to secure a sustainable and thriving future for all? The Innovation invites you to contribute to a groundbreaking initiative aimed at identifying the top 100 challenges humanity must address. This effort will foster collaboration across disciplines and ignite global action to tackle the most pressing issues of our time.

A critical moment for humanity

From climate change to the rise of artificial intelligence, humanity stands at a pivotal crossroads. The sixth mass extinction looms, ecosystems are under unprecedented strain, and technological advancements bring both opportunity and risk. As global citizens, we must take collective responsibility for our planet and future generations.

Throughout history, progress has been driven by addressing significant, far-reaching issues. In critical moments of human development, exploring these problems—rooted in fundamental scientific theories—has sparked collective efforts to overcome challenges. The enduring initiative of identifying and solving these problems has inspired researchers worldwide to expand the boundaries of human knowledge. This effort goes beyond curiosity, focusing on the solutions that will shape our collective future.

Join the global conversation

This is a call to action for all: scientists, engineers, policymakers, students, and anyone with an idea or vision for a better future. Multidisciplinary collaboration is essential to addressing complex global issues, and your insights are vital to this mission. Together, we can shape the course of human civilization.

We invite you to propose a challenge that you believe humanity must address (Figure 1). Your submission should include a title and a brief description (<500 words) explaining why this challenge is critical and how addressing it could create meaningful change.