Asymmetric inheritance of parental histones leads to differentiation defects in mouse embryonic stem cells
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REFERENCES
[1] Wen, Q., Zhou, J., Tian, C., et al. (2023). Symmetric inheritance of parental histones contributes to safeguarding the fate of mouse embryonic stem cells during differentiation. Nat. Genet. 55 : 1555−1566. DOI: 10.1038/s41588-023-01477-w. [2] Yu, C., Gan, H., Serra-Cardona, A., et al. (2018). A mechanism for preventing asymmetric histone segregation onto replicating DNA strands. Science 361: 1386−1389. DOI: 10.1126/science.aat8849. [3] Wenger, A., Biran, A., Alcaraz, N., et al. (2023). Symmetric inheritance of parental histones governs epigenome maintenance and embryonic stem cell identity. Nat. Genet. 55: 1567−1578. DOI: 10.1038/s41588-023-01476-x. [4] Buitrago, D., Labrador, M., Arcon, J.P., et al. (2021). Impact of DNA methylation on 3D genome structure. Nat. Commun. 12: 3243. DOI: 10.1038/s41467-021-23142-8. [5] Xie, J., Wooten, M., Tran, V., et al. (2015). Histone H3 threonine phosphorylation regulates asymmetric histone inheritance in the drosophila male germline. Cell 163: 920−933. DOI: 10.1016/j.cell.2015.10.002. -
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Yang X., Karri S., and Yu C. (2024). Asymmetric inheritance of parental histones leads to differentiation defects in mouse embryonic stem cells. The Innovation Life 2(1): 100047. https://doi.org/10.59717/j.xinn-life.2024.100047
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Yang X., Karri S., and Yu C. (2024). Asymmetric inheritance of parental histones leads to differentiation defects in mouse embryonic stem cells. The Innovation Life 2(1): 100047. https://doi.org/10.59717/j.xinn-life.2024.100047
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Figure 1.
Schematic representing asymmetric inheritance of parental histones in DNA replication as a result of the mutation of Mcm2-2A or the deletion of Pole3, and the resulting functional and differentiation defects in mouse embryonic stem cells (mESCs).
