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REFERENCES
[1] Zhang, Z.Y., Harischandra, D.S., Wang, R., et al. (2023). TRIM11 protects against tauopathies and is down-regulated in Alzheimer's disease. Science 381: eadd6696. DOI: 10.1126/science.add6696. [2] Jena, K.K., Kolapalli, S.P., Mehto, S., et al. (2018). TRIM16 controls turnover of protein aggregates by modulating NRF2, ubiquitin system, and autophagy: Implication for tumorigenesis. Mol. Cell Oncol. 5: e1532251. DOI: 10.1080/23723556.2018.1532251. [3] Chen, L., Zhu, G., Johns, E.M., et al. (2018). TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14. Nat. Commun. 9: 1223. DOI: 10.1038/s41467-018-03499-z. [4] Zhu, G., Harischandra, D.S., Ghaisas, S., et al. (2020). TRIM11 prevents and reverses protein aggregation and rescues a mouse model of Parkinson's disease. Cell Rep. 33: 108418. DOI: 10.1016/j.celrep.2020.108418. [5] Chen, L., Brewer, M.D., Guo, L., et al. (2017). Enhanced degradation of misfolded proteins promotes tumorigenesis. Cell Rep. 18: 3143−3154. DOI: 10.1016/j.celrep.2017.03.010. -
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Xu Y., Kwok H., and Chen L. (2024). TRIM11: A powerful guardian of proteostasis. The Innovation Life 2(1): 100048. https://doi.org/10.59717/j.xinn-life.2024.100048
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Xu Y., Kwok H., and Chen L. (2024). TRIM11: A powerful guardian of proteostasis. The Innovation Life 2(1): 100048. https://doi.org/10.59717/j.xinn-life.2024.100048
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Figure 1.
The dual role of TRIM11 in cancer and neurodegenerative diseases.
