Co-evolve strategy for the discovery of genetic “dark matter”
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REFERENCES
[1] Huang, J., Zhong, X.-F., and Gao, Y.-Z. (2024). New antibiotic against multi-drug resistant bacteria. The Innovation Life 2: 100057. DOI: 10.59717/j.xinn-life.2024.100057. [2] Uguru, G.C., Stephens, K.E., Stead, J.A., et al. (2005). Transcriptional activation of the pathway-specific regulator of the actinorhodin biosynthetic genes in Streptomyces coelicolor. Mol. Microbiol. 58: 131−150. DOI: 10.1111/j.1365-2958.2005.04817.x. [3] Wang, W., Li, S., Li, Z., et al. (2020). Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces. Nat. Biotechnol. 38: 76−83. DOI: 10.1038/s41587-019-0335-4. [4] Gavriilidou, A., Kautsar, S.A., Zaburannyi, N., et al. (2022). Compendium of specialized metabolite biosynthetic diversity encoded in bacterial genomes. Nat. Microbiol. 7: 726−735. DOI: 10.1038/s41564-022-01110-2. [5] Wang, X., Chen, N., Cruz-Morales, P., et al. (2024). Elucidation of genes enhancing natural product biosynthesis through co-evolution analysis. Nat. Metab. 6 : 933-946. DOI: 10.1038/s42255-024-01024-9. -
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Wang X., Li Z., Chen N., et al., (2024). Co-evolve strategy for the discovery of genetic “dark matter”. The Innovation Life 2(2): 100071. https://doi.org/10.59717/j.xinn-life.2024.100071
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Wang X., Li Z., Chen N., et al., (2024). Co-evolve strategy for the discovery of genetic “dark matter”. The Innovation Life 2(2): 100071. https://doi.org/10.59717/j.xinn-life.2024.100071
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Figure 1.
Illustration of the co-evolve strategy workflow for natural products discovery and overproduction (left) and the underlying mechanism for natural product overproduction resulted from introduction of the PQQ gene cluster in Streptomyces coelicolor (right). TAG: triacylglycerol; GPL: glycerol-phospholipid.
